2014 Fiscal Year Final Research Report
The role of intracellular muscarinic M1 receptor in the regulation of synaptic plasticity and spatial memory
| Project/Area Number |
25870852
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
Neurochemistry/Neuropharmacology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ムスカリン受容体 / シナプス伝達長期増強 / 海馬 / 空間記憶課題 |
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| Outline of Final Research Achievements |
Muscarinic acetylcholine receptors are well known to broadly express in brain and contribute to neuropsychological function such as memory and emotion. In present study, we performed experiments to clarify the regulatory mechanism of hippocampal long-term potentiation (LTP) mediated by intracellular M1 receptor expressing in Golgi and endoplasmic reticulum, and the contribution of the intracellular M1 receptor on spatial memory. As a result, it was suggested that intracellular M1 receptor expressing postsynaptic neurons facilitates the efficiency of synaptic transmission on postsynaptic membrane. On the other hand, it was also revealed that LTP facilitation induced by intracellular M1 receptor hardly affect spatial learning.
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| Free Research Field |
神経薬理学
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