2015 Fiscal Year Final Research Report
Role of Sphingomyelin/lipid raft on Japanese encephalitis virus infection
| Project/Area Number |
25870853
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Virology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | スフィンゴミエリン / スフィンゴミエリン合成酵素 / 日本脳炎ウイルス / ウイルス感染 / ウイルス接着 / スフィンゴ脂質 |
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| Outline of Final Research Achievements |
Sphingomyelin(SM) is a main component of cellular lipid bylaer membranse and implicates in various cellular functions such as proliferation, migration, and virus infection. The Japanese encephalitis virus (JEV) belongs to the Flaviviridae, infects via mosquitoes, and causes severe encephalitis. The E protein of JEV is necessary for the attachment and infection to target cells.
However, its celllular target factors are unknown. In this study, I showed that deficiency of SM synthesis inhibits JEV infection both cells and mice. This study provides new insight for developing the novel therapeutic approaches to prevention of JEV infection and enchephalitis.
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| Free Research Field |
脂質生化学
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