Efficacy and mechanism of dietary intervention for nonalcoholic steatohepatitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870865
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits; Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kinjo Gakuin University
• Principal Investigator: TAMADA Hazuki 金城学院大学, 生活環境学部, 助教 (70581403)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 非アルコール性脂肪性肝炎 / 食事療法 / メタボリックシンドローム / SHRSP5/Dmcr

Outline of Final Research Achievements

Nonalcoholic steatohepatitis (NASH) is related to lifestyle, particularly dietary habit. We developed dietary-induced fibrotic steatohepatitis model SHRSP5/Dmcr. We aimed to clarify the efficacy of dietary intervention for the disease. Male SHRSP5/Dmcr were divided into control, NASH and intervention groups. The intervention groups were fed control diet as dietary intervention after high-fat and -cholesterol diet feeding before/after hepatic fibrosis appeared. The intervention before fibrosis appeared significantly improved the steatosis, and reset the increased some serum parameters. However, the intervention after fibrosis appeared was no influence the formed hepatic fibrosis contents, though it improved the increased TGF-β1 and α-SMA expressions. Together, dietary intervention for fibrotic steatohepatitis improved steatosis, while could not show any improvement of fibrosis, though improved the signal transduction of fibrosis.

Free Research Field

総合領域、生活科学、食生活学