The analysis of lipid metabolism changes by short sleep duration and smoking

2016 Fiscal Year Final Research Report

• Project/Area Number: 25870868
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Laboratory medicine
• Research Institution: Nagoya University (2014-2016); Chubu University (2013)
• Principal Investigator: MIYATA Seiko 名古屋大学, 医学系研究科, 寄附講座助教 (40560917)
• Research Collaborator: NODA Akiko 中部大学, 臨床検査技術教育・実習センター, 教授 (80252287) ; TAGUCHI Ryo 中部大学, 生命健康科学部, 教授 (20080210)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 生活習慣病 / 脂質 / 質量分析

Outline of Final Research Achievements

We studied the effect of short sleep duration and smoking on lipid metabolic changes and brain and endothelial function. Three nights of sleep restriction reduced the cortical oxygenation response during cognitive task compared to that in natural sleep. Endothelial function after smoking was significantly impaired than that at rest in young smokers. We identified significant changes of 168, 72 and 39 lipid species between natural sleep and sleep restriction, smokers and non-smokers, and pre- and post-smoking using electrospray ionization mass spectrometry.

Free Research Field

睡眠医学