2016 Fiscal Year Final Research Report
Relationship between the mode change of migrating neuron and vascular network in the developing cerebral cortex
| Project/Area Number |
25870900
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
General medical chemistry
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| Research Institution | Tohoku Medical and Pharmaceutical University (2016)
Doshisha University (2013-2015) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 発生学・形態形成学 / 発生医学 |
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| Outline of Final Research Achievements |
During brain formation, post-mitotic neurons migrate through the developing vascular network. To analyze their interaction, we first analyzed the mechanisms that control the morphological changes of migrating neurons. By using the ex vivo slice culture system of the cerebral cortex, it became clear that Cdk5, p27kip1, JNK etc. are involved. We also attempted time-lapse observation to analyze the detailed formation process of the vascular network. However, since the vascular network collapsed early in the slice tissue, we failed to record the normal morphological changes and analyze the molecular mechanism.
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| Free Research Field |
神経発生学
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