2014 Fiscal Year Final Research Report
Antitumor effect of newly synthesized naftopidil derivatives on malignant pleural mesothelioma.
| Project/Area Number |
25870965
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
Respiratory organ internal medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
KANNO TAKESHI 兵庫医科大学, 医学部, 准教授 (20434946)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 悪性胸膜中皮腫 |
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| Outline of Final Research Achievements |
We newly synthesized 21 naftopidil derivatives, and of them 1-[2-(2-methoxyphenylamino) ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol (HUHS1015) most efficiently reduced cell viability for all the investigated malignant mesothelioma cell lines NCI-H28, NCI-H2052, NCI-H2452,and MSTO-211H. HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma.
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| Free Research Field |
生理学
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