2014 Fiscal Year Final Research Report
Molecular mechanisms of nicotine dependence and relapse after ethanol vapor inhalation
| Project/Area Number |
25870974
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
Psychiatric science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 薬物依存 / ニコチン / アルコール / 細胞内カルシウム |
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| Outline of Final Research Achievements |
Ethanol (EtOH) and nicotine have been frequently reported to be co-abused in humans, because EtOH and nicotine are legal and readily available. Several studies have showed that approximately 80% of EtOH-dependent people are smokers and EtOH use is a risk factor for nicotine use. The present study investigated whether the development of nicotine-induced place preference could be modified by exposure of EtOH vapor inhalation prior to nicotine administration and how RyRs participate in the sensitization of nicotine-induced place preference in mice after continuous EtOH vapor inhalation. These results suggest that the facilitated nicotine-induced place preference after 3 days of withdrawal from EtOH inhalation for 6 days is due to up-regulated RyRs-2 via α7 nAChR activation in dopaminergic neurons of the posterior VTA.
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| Free Research Field |
医歯薬学
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