2014 Fiscal Year Final Research Report
Development of novel metal-free reaction triggered by reactive unsaturated bond
| Project/Area Number |
25870983
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
Drug development chemistry
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | タンデム反応 / メタルフリー / アルキン |
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| Outline of Final Research Achievements |
A cleavage reaction of carbon-carbon triple bond of electron-rich diarylalkynes proceeds with N-iodosuccinimide and trimethylsilylazide, giving the corresponding nitriles in moderate to good yields. The reaction of aryl alkyl alkynes affords α,α-diazidoketones via the regioselective iodoazidation of alkynes. Electron-rich primary propargyl alcohols undergo bismuth(III)-catalyzed Meyer－Schuster rearrangement and successive 1,4-addition of alcohol to give β-alkoxyketones.
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| Free Research Field |
有機化学
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