Construction of new neurotrophic factor replacement therapy for dimentia by yokukansan

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870997
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Natural medicines; General pharmacology
• Research Institution: Fukuoka University
• Principal Investigator: KUBOTA Kaori 福岡大学, 薬学部, 助教 (60380557)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 神経栄養因子 / 認知症 / 漢方薬

Outline of Final Research Achievements

Neurotrophic factor-like activity of Kampo medicine Yokukansan (YKS) is considered useful as a neurotrophic factor replacement therapy. We were focused on the neurite outgrowth action, the activation of the signal transduction system of neurotrophic factors, and the biosynthesis promoting action of neurotrophic factor, and clarified the pharmacological mechanism of neurotrophic factor-like action on YKS and herbal components. As a result, these neurotrophic factor-like action of YKS was confirmed on cell-based researches. Furthermore, it was revealed that YKS affects the neurotrophic factors, and also indicate the cell protection and cognitive improvement in dementia model animals. From the results of this study, it has been further expected usefulness as a dementia treatment of YKS.

Free Research Field

分子薬理学