2014 Fiscal Year Final Research Report
STAT3 mediated acquisition of stem cell features in glioblastoma cells
| Project/Area Number |
25871006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
Pathological medical chemistry
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 癌幹細胞 / 神経膠芽腫 / STAT3 / リプログラミング |
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| Outline of Final Research Achievements |
Cancer stem cells (CSC) is implicated in the resistance to chemotherapy. We hypothesized that CSC could be induced by cellular stress such as chemotherapeutic agents through activation of STAT3.
We observed high levels of phosphorylated STAT3 in human glioblastoma (GBM) samples together with high levels of stem cell markers such as Sox2, 5-lipoxygenase etc. Stem cell markers are induced by cellular stress, which can be regulated by endogenous micro RNA-302/367 cluster. These findings provide a novel insight into CSC-targeted therapy for GBM.
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| Free Research Field |
腫瘍学
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