Identification of novel tyrosine kinase fusion genes in colorectal cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 25871072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology; Experimental pathology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: SAKATA Seiji 公益財団法人がん研究会, 分子標的病理プロジェクト, 研究員 (00617433)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: チロシンキナーゼ / 融合遺伝子

Outline of Final Research Achievements

We found several novel tyrosine kinase fusion genes in colorectal cancer using a histopathology-based screening system. We analyzed clinicopathological data and other gene mutations in colorectal cancers with the identified fusion genes. We are investigating tumorigenicity and drug sensitivity of the identified fusion genes.

Free Research Field

人体病理学