Effect of Neurokinin B on the activity of the GnRH pulse generator

2015 Fiscal Year Final Research Report

• Project/Area Number: 25871109
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science; Animal production science
• Research Institution: National Institute of Agrobiological Sciences
• Principal Investigator: Wakabayashi Yoshihiro 国立研究開発法人農業生物資源研究所, 動物生産生理機能研究ユニット, 主任研究員 (00510695)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: キスペプチン / neurokinin B / 弓状核

Outline of Final Research Achievements

Neurokinin B (NKB) in the arcuate nucleus (ARC) kisspeptin neurons might regulate the pulsatile secretion of GnRH/luteinizing hormone (LH) in mammals, however physiological function of NKB still remains unclear. To verify the physiological function of NKB, goats bearing the guide cannula with recording electrodes in the ARC, where kisspeptin neurons are located, were received micro injection of NKB. The local injection of NKB evoked bursts of the ARC kisspeptin neurons and following secretion of LH. These findings suggest that NKB in the ARC kisspeptin neurons stimulates the neural activity of the ARC kisspeptin neurons to burst simultaneously. This burst might be neural source of the pulsatile secretion of GnRH/LH.

Free Research Field

農学