Regulation of myoblast differentiation through the endoplasmic reticulum (ER) membrane dynamics caused by ER stress

2016 Fiscal Year Final Research Report

• Project/Area Number: 25871124
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cell biology; General anatomy (including histology/embryology)
• Research Institution: Nara Institute of Science and Technology (2016); Institute of Physical and Chemical Research (2013-2015)
• Principal Investigator: Nakanishi Keiko 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (30415252)
• Research Collaborator: MORISHIMA NOBUHIRO 国立研究開発法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 (40182232)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 細胞分化 / 小胞体ストレス / オルガネラ動態 / 筋芽細胞 / カルシウム / STIM1

Outline of Final Research Achievements

We previously reported that endoplasmic reticulum (ER) stress signaling caused physiologically during myoblast differentiation plays important roles for the differentiation. However, the mechanism which causes the ER stress signaling was unknown. We investigated correlation between ER membrane dynamics and alterations in ER homeostasis, and revealed that ER calcium depletion is the cause of ER stress during myotube formation.

Free Research Field

細胞生物学