An attempt to improve low chemotherapy sensitivity of ovarian clear cell carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 25871147
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology; Obstetrics and gynecology
• Research Institution: Sasaki Foundation
• Principal Investigator: KIKUCHI Ryoko 公益財団法人佐々木研究所, 附属研究所, 研究員(移行) (80535063)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 卵巣明細胞腺癌 / パクリタキセル / 分子標的治療 / 蛍光標識二次元ディファレンスゲル電気泳動法

Outline of Final Research Achievements

We used 4 ovarian clear cell carcinoma cell lines to identify 2 paclitaxel sensitive cell lines and 2 paclitaxel resistant cell lines. We used 2 Dimensional Fluorescence Difference Gel Electrophoresis (2D-DIGE) to identify 4 proteins that have high protein expressions in 2 paclitaxel resistant cell lines in common and low protein expressions in 2 paclitaxel sensitive cell lines in common. One of the 4 proteins was protein 1 (labo name). Protein 1 was reported to induce drug resistance in other carcinoma, but was not reported to induce drug resistance in ovarian clear cell carcinoma. Protein 1 might be a new candidate of paclitaxel sensitive marker and protein 1-targeted therapy might enhance paclitaxel sensitivity of ovarian clear cell carcinoma.

Free Research Field

婦人科腫瘍学