Cost-effectiveness analysis of colorectal cancer screening using colonoscopy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25871160
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical sociology; Gastroenterology
• Research Institution: National Cancer Center Japan
• Principal Investigator: SEKIGUCHI MASAU 独立行政法人国立がん研究センター, 中央病院, がん専門修練医 (50648342)
• Research Collaborator: MATSUDA Takahisa ; IGARASHI Ataru ; SAITO Yutaka
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 大腸がん検診 / 費用対効果分析 / 大腸内視鏡検査 / 便潜血検査

Outline of Final Research Achievements

There have been few cost-effectiveness analyses of population-based colorectal cancer (CRC) screening in Japan. This study examined the cost-effectiveness of CRC screening with total colonoscopy (TCS) and the fecal immunochemical test (FIT) using Japanese data. We developed a Markov model to assess the cost-effectiveness of three CRC screening strategies: 1) a TCS-based strategy; 2) a FIT-based strategy; 3) a strategy of adding population-wide TCS at a specified age to a FIT-based strategy. Among the three, strategy 1 was the most cost-effective, followed by strategy 3. However, strategy 1 required more than double the number of TCS procedures than the other strategies. Based on the results, we postulate that more active use of TCS than a FIT-based strategy could result in better cost-effectiveness. Considering the cost-effectiveness and TCS workload together, strategy 3 may be an optimal solution.

Free Research Field

消化器内科、消化管内視鏡