Estabishment of dose volume constraints of organs at risk in image-guided intensity-modulated radiation therapy for prostate cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 25871226
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science; Urology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: TOMITA Natsuo 愛知県がんセンター(研究所), 疫学・予防部, 研究員 (60643781)
• Research Collaborator: OZE Isao 愛知県がんセンター(研究所), 疫学・予防部, 研究員 (00584509)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 前立腺癌 / 強度変調放射線治療 / 直腸障害 / 線量制約 / 画像誘導下放射線治療

Outline of Final Research Achievements

The availability of image-guided intensity-modulated radiation therapy is expected for prostate cancer. The late rectal toxicity is the most important problem in high-dose external beam radiation therapy for prostate cancer. Late rectal toxicity was 7.4% after image-guided intensity-modulated radiation therapy in this study. The result of this study indicates that the risk of late rectal toxicity correlates with the rectal volume exposed to high doses of image-guided intensity-modulated radiation therapy, and the percentage of the rectum covered by 70 Gy and 60 Gy are needed to keep below at least 10% and 18%, respectively.

Free Research Field

放射線治療