The elucidation of inflammatory response mechanism in the hyperoxic condition during extracorporeal circulation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25871231
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery; General surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: FUJII Yutaka 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (20589303)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 体外循環 / 高酸素 / 活性酸素 / 炎症反応 / サイトカイン

Outline of Final Research Achievements

Systemic inflammatory responses in patients receiving cardiac surgery supported by cardiopulmonary bypass (CPB) significantly contribute to CPB-associated morbidity and mortality. We hypothesized that hyperoxia insufflation aggravates the inflammatory responses and organ damage during CPB. To verify this hypothesis, we investigated the inflammatory responses at high and normal levels of arterial pressure of oxygen (PaO2) in the rat CPB model.
In this study suggest that it is better to avoid too much oxygen insufflation for
attenuating organ damage associated with the superoxide production and inflammatory responses during CPB.

Free Research Field

循環生理学　体外循環学　臨床工学