2014 Fiscal Year Final Research Report
Analyses of vascular lumen formation by in vivo imaging
| Project/Area Number |
25871232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
Morphology/Structure
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
HIROYUKI Nakajima 独立行政法人国立循環器病研究センター, 研究所, 研究員 (10467657)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 血管形成 |
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| Outline of Final Research Achievements |
We constructed transgenic zebrafish lines that can label apical membranes and cell-cell junctions specifically in endothelial cells. By using these lines, we have revealed that some processes of lumen formation are driven by blood flow. In addition, we found that YAP1, a target of the Hippo pathway, translocated into the nucleus just after lumen formation. Finally, we have demonstrated that YAP1 is regulated by blood flow after lumen formation.
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| Free Research Field |
血管生物学
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