2014 Fiscal Year Final Research Report
The treatment benefit of ghrelin on a mouse model of inherited dilated cardiomyopathy caused by troponin mutation
| Project/Area Number |
25871236
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
General pharmacology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
ZHAN DONGYUN 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 (30616941)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 拡張型心筋症 / ノックインマウス / 生理活性ペプチド / 心臓自律神経活動 / 心拍変動 |
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| Outline of Final Research Achievements |
We examined whether ghrelin is beneficial for the treatment of inherited dilated cardiomyopathy (DCM) with a deletion mutation ΔK210 in the cardiac troponin T gene using a knock-in mouse model.We found that ghrelin administration for one month suppressed the excessive cardiac sympathetic nerve activity and recovered the cardiac parasympathetic nerve activity and then prevented sudden death and left ventricular remodeling of DCM mice. These results suggested that cardiovascular benefits of ghrelin are likely linked to the suppression of CSNA and recovery of cardiac parasympathetic nerve activity.
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| Free Research Field |
循環器内科学、薬理学
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