A study on the effect of cardiomyocyte intracellular urtrastructure and functional molecures by integrated simulation with realistic cardiomyocyte mesh

2014 Fiscal Year Final Research Report

• Project/Area Number: 25882010
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokyo
• Principal Investigator: HATANO Asuka 東京大学, 工学(系)研究科(研究院), 助教 (20707202)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 心筋細胞 / 収縮 / マルチフィジックスシミュレーション / 三相理論 / ミトコンドリア

Outline of Final Research Achievements

We realized multiphysics simulation integrating biophysiological, electrical and mechanical phenomena of cardiomyocyte using the mesh constructed based on the electron micrograph taken and segmented by our collaborator. The mesh contain the segment of half sarcomere length and spans one quarter of the cardiomyocyte cross-section, containing 12 myofibrils. We included randomness in the t-tubule morphology and in the mitochondrial location, and discussed the effect of the randomness on the contraction of cardiomyocyte. We evaluated distribution of electrical potential along t-tubule at the onset of depolarization and fluid exchange between t-tubule and extracellular space during contraction.

Free Research Field

生体シミュレーション