Construction of three dimensional tissue with vessel-like structures

2014 Fiscal Year Final Research Report

• Project/Area Number: 25882012
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokyo
• Principal Investigator: HIRAYAMA Kayoko 東京大学, 情報理工学(系)研究科, 特任研究員 (60710564)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 再生医療 / 医用材料 / バクテリアセルロース

Outline of Final Research Achievements

I fabricated microfiber, which served as a scaffold for mammalian cells. The microfibers were consists of nanofibrous cellulose secreted by bacteria (bacterial cellulose). The aim of this study is to fabricate vessel-like structure by culturing cells on the microfibers and three-dimensional cellular constructs. I achieved fabrication of three-dimensional cellular constructs which had heterocellular hierarchic structure. I also found an enzyme suitable for degrading the bacterial cellulose fibers after the fabrication of cellular construct. Furthermore, the nutrition diffusion model was fabricated to calculate the maximum culturable time of the cellular constructs without necrosis.

Free Research Field

BioMEMS