Spatiotemporal analysis of cell movement based on near-infrared responsive stiffness controlled polymeric hydrogels

2014 Fiscal Year Final Research Report

• Project/Area Number: 25882048
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo University of Science (2014); National Institute for Materials Science (2013)
• Principal Investigator: KAMIMURA Masao 東京理科大学, 基礎工学部, 助教 (80706888)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: バイオマテリアル / ゲル / 細胞接着 / ECM / 細胞移動 / メカノバイオロジー

Outline of Final Research Achievements

The purpose of this study is preparation of near-infrared light stimuli responsive polymeric hydrogel and application for cell culture substrate. Stiffness controlled polyacrylamide gel was prepared as the substrate. Additionally, as a cross-linker, near-infrared excited nanoparticle, rare-earth doped ceramic nanoparticles was also synthesized. The surface of nanoparticle was effectively modified by poly(ethylene glycol) based block copolymer. The obtained materials can be applied for preparation of near-infrared light stimuli responsive polymeric hydrogel.

Free Research Field

バイオマテリアル