2014 Fiscal Year Final Research Report
Investigation of modification for human telomeric RNA
| Project/Area Number |
25888019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Bio-related chemistry
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | テロメアDNA / ヒトテロメアRNA / 四重鎖構造 / 核酸 / ねじれ角 / トポロジー / 8,2'-環状グアノシン / 5',8-環状グアノシン |
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| Outline of Final Research Achievements |
In this study, human telomeric RNA oligonucleotides incorporating a conformationally restricted nucleoside such as 8,2’-O-cycloguanosine and 5’,8-cycloguanosine were synthesized and evaluated for their structural properties to find out new functions on the G-quadruplex structure. As main results, we found that introductions of the conformationally restricted nucleosides into human telomeric RNA oligonucleotides induced the helicity and topology changes on the G-quadruplex structure. These results would be valuable to analyze the structures and function of the human telomeric RNA.
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| Free Research Field |
化学
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