Development of the tailor-made biosynthesis system of aromatic compounds using microbe

2014 Fiscal Year Final Research Report

• Project/Area Number: 25889071
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biofunction/Bioprocess
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: NODA Shuhei 独立行政法人理化学研究所, 環境資源科学研究センター, 特別研究員 (30710131)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: Kluyveromyces lactis / NADPH / アセチル-CoA / Tyrosine decarboxylase

Outline of Final Research Achievements

And it was cultured characterization for a variety of yeast , were screened for ethanol non-production type yeast . As a result , we have found that for the kind of Kluyveromyces lactis, hardly produce ethanol . As a result of this K. further lactis strain analysis , coenzymes and the like ATP and NADPH involved in the conversion into various useful substances , are important intracellular substance such as acetyl coenzyme A to be the skeleton of various useful substances , S . it was found that are significantly more storage compared to cerevisiae. K. lactis were screened in this study , suggesting that it can become a platform for the production by fermentation of various useful substances. In addition, some enzymes to modify aromatic residues can be successfully screened. We here constructed research base for "tailor-made biosynthesis system of aromatic compounds."

Free Research Field

生物化学工学