Identification of surrogate plasma markers for early diagnosis of Alzheimer's disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 25889072
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biofunction/Bioprocess
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TSUKAKOSHI Kaori 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (20708474)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: アルツハイマー病 / 早期診断 / バイオマーカー

Outline of Final Research Achievements

Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Abeta) and tau deposition. It is revealed that Abeta plaques emerge first in progression of AD; therefore the blood-based biomarker to detect Abeta deposition is useful for early diagnosis of AD.
We performed screening of blood-based biomarkers in AD model mice that we recently developed by using 2D-DIGE and identified four marker candidate proteins. We are validating those candidates by ELISA and aptamer-based assay.

Free Research Field

神経科学