Revealing NF-kB signal transduction system by experiment and simulation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25890025
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: System genome science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: INOUE Kentaro 独立行政法人理化学研究所, 統合生命医科学研究センター, 特別研究員 (80708529)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: NF-kB / シグナル伝達システム / シミュレーション / モデリング

Outline of Final Research Achievements

Transcription factor nuclear factor kappa B (NF-kB) is related to cell fate decision and various diseases. Mathematical model for NF-kB signal transduction system is useful to understand a regulatory mechanism of NF-kB activation. Previous models for NF-kB system can reproduce an oscillatory behavior for NF-kB activity. In this study, we constructed a model which reproduces not only the oscillatory behavior but also a switch-like response for NF-kB activity. This model is the largest model explaining a lot of experiments in NF-kB system.

Free Research Field

システム生物学