Comparative evolutionary analysis of endogenous viral elements among mammals

2014 Fiscal Year Final Research Report

• Project/Area Number: 25891023
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Evolutionary biology
• Research Institution: Tokai University
• Principal Investigator: NAKAGAWA So 東海大学, 医学部, 助教 (70510014)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 比較ゲノム / 内在性レトロウイルス / レトロトランスポゾン / ジャンクDNA / 分子進化 / バイオインフォマティクス / ゲノム進化 / データベース

Outline of Final Research Achievements

Using 20 genomes from 19 mammalian species, we identified 736,765 nucleotide sequences that are possibly derived from viruses (called EVE). For each sequence, its locus, amino acid and nucleotide sequences, functional motifs, and similar endogenous/exogenous viral sequences were annotated. These results are publically available via a database (gEVE, http://geve.med.u-tokai.ac.jp).

Free Research Field

生物学