2014 Fiscal Year Final Research Report
Development of analytical method for the organohalogen metabolites elucidation of metavolic capacities and risk assessment in the pet cat
| Project/Area Number |
25892001
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
MIZUKAWA Hazuki 北海道大学, (連合)獣医学研究科, 助教 (60612661)
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| Research Collaborator |
ISHIZUKA Mayumi 北海道大学, 大学院獣医学研究科・毒性学教室, 教授
IKENAKA Yoshinori 北海道大学, 大学院獣医学研究科・毒性学教室, 准教授
NAKAYAMA Shouta 北海道大学, 大学院獣医学研究科・毒性学教室, 助教
TAKIGUCHI Mitsuyoshi 北海道大学, 大学院獣医学研究科・内科学教室, 教授
NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センター化学汚染・毒性解析部門, 准教授
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | ネコ / 有機ハロゲン化合物 / 血清 / 環境分析 / 水酸化代謝物 / ペット / 第I相反応 / 第II相反応 |
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| Outline of Final Research Achievements |
This study was develop the analyzing method for hydroxylated polybrominated diphenyl ethers (OH-PBDEs) and the glucuronidation compounds of OH-PCBs using liquid chromatography tandem mass spectrometry (LC-MS/MS). Moreover, it was measured the glucuronidation activities using the liver microsomes of the cats. I also attempted the evaluation of metabolic capacities of PCBs and PBDEs in the cats.
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| Free Research Field |
環境化学
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