2014 Fiscal Year Final Research Report
Structural brain abnormality in heart failure rats
| Project/Area Number |
25893010
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | 循環器内科 / 心不全 / 海馬 / 脳 / うつ / MRI |
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| Outline of Final Research Achievements |
In 2013, we demonstrated that brain magnetic resonance imaging and behavioral tests revealed significant reduction in gray matter in the hippocampus and increase in depressive symptoms respectively in HF rats compared with sham rats. In 2014, brain histological analysis reviealed significant decrease in neurogenesis and neurite outgrowth and increase in the number of astrocytes in the hippocampus in HF rats compared with sham rats. Gray matter in the hippocampus was significantly correlated with depressive symptoms in HF rats. Therefore, the results of this study demonstrated for the first time that the structural abnormality of the hippocampus is associated with depressive symptoms in HF and has been accepted in the peer-reviewd journal, NeuroImage.
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| Free Research Field |
循環器内科
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