2014 Fiscal Year Final Research Report
Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations
| Project/Area Number |
25893026
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | アルドステロン産生腺腫 / KCNJ5遺伝子変異 |
|---|
| Outline of Final Research Achievements |
Somatic mutations of the potassium channel KCNJ5 gene have been recently identified in patients with adrenal aldosterone-producing adenomas (APAs). In the present study,we identified 76% of KCNJ5 mutations in APAs. They were younger and showed higher plasma aldosterone levels, lower potassium levels and higher diastolic blood pressure(p<0.05,p<0.05, p<0.01 and p<0.05, respectively). Reflecting these phenotypes, they had higher CYP11B2 mRNA levels. However, in contrast to APAs in Western countries, Japanese APAs with mutations showed lower CYP11B1, CYP17A1, and CYP11A1 mRNA levelsp<0.01,p<0.02, p<0.01 and p<0.05, respectively). These findings demonstrated that Japanese APAs may have distinct features including a higher prevalence of KCNJ5 mutations and characteristics similar to the zona glomerulosa.
|
| Free Research Field |
内分泌学
|
