2014 Fiscal Year Final Research Report
The analysis of ASK1 pathway in brown adipocytes
| Project/Area Number |
25893036
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HATTORI Kazuki 東京大学, 薬学研究科(研究院), 特任助教 (40708575)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | 褐色脂肪 / ASK1 / Ucp1 / 熱産生 / 脂肪分化 |
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| Outline of Final Research Achievements |
Brown adipose tissue is in the spotlight as a therapeutic target for some metabolic diseases. We revealed that the expression levels of specific subset of genes, which are known to be involved in thermogenesis, were suppressed in ASK1-deficient brown adipose tissue by DNA microarray analysis. Further analysis using primary culture of brown adipocytes elucidated that PKA-ASK1-p38 pathway is activated during the course of differentiation, which leads to gene induction, including Ucp1, and induces maturation of brown adipocytes.
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| Free Research Field |
細胞内シグナル伝達
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