2014 Fiscal Year Final Research Report
Formation of stress granules participates in the regulation of cell death in neurodegenerative diseases
| Project/Area Number |
25893040
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | ストレス応答 / ストレス顆粒 / 酸化ストレス / 小胞体ストレス / 細胞死 |
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| Outline of Final Research Achievements |
Stress granules (SGs) are phase-dense particles that appear in the cytoplasm of eukaryotic cells that have been exposed to certain types of stress such as arsenite, hypoxia, and ER stress. By assembling SGs, cells shut down protein synthesis temporarily to prevent accumulation of mis-folded proteins. SGs also contribute to cell survival under stressful conditions by sequestering some apoptosis regulating factors and suppressing their functions.
In this study, I focused on the regulation of SG formation under multiple stess conditions which are often seen in various severe diseases. In neurodegenerative diseases, cells undergo cell death because of multi-stress, ER stress and oxidative stress. Here I found that in oxidative conditions, ER stress cannot induce SG formation, rendering cells vulnerable to cell death. By establishing model cell line for one of typical neurodegenerative disorders, I confirmed that neuronal cell death is promoted by SG suppression.
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| Free Research Field |
細胞生物学
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