Development of a novel therapy for promoting liver regeneration and preventing postoperative therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893052
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: INAGAKI Fuyuki 東京大学, 医学部附属病院, 登録研究医 (70529015)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 再生医療 / 肝切除 / 術後癒着

Outline of Final Research Achievements

Repeated hepatectomy is widely accepted as one of the potentially curative treatments for primary and secondary liver neoplasms. But repeated hepatectomy has two major problems; postoperative adhesion and decreased regenerating ability of the remnant liver. We have already reported that the transplantation of mesothelial progenitor cells prevented postoperative adhesion and promoted liver regeneration in the mice practical partial hepatectomy model. In this study, we revealed the anti-adhesive effect of mesothelial cells transplantation in the miniature pig hepatectomy model. In addition, we showed that an allogeneic transplantation was as effective as a syngeneic transplantation in mice.

Free Research Field

肝胆膵外科学