2014 Fiscal Year Final Research Report
A rat model of posterior nasal neurectomy.
| Project/Area Number |
25893055
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | アレルギー性鼻炎 / 後鼻神経切断術 / 鼻粘膜 / アレルギー / 鼻汁分泌 / 神経免疫 |
|---|
| Outline of Final Research Achievements |
We investigated the neural regulation of posterior nasal nerve on the nasal respiratory mucosa, especially in the pathophysiology of allergic rhinitis. We developed a rat model of posterior nasal neurectomy (PNN). We investigated the influence of impaired innervation on the nasal respiratory mucosa and the effect of PNN for the allergic rhinitis model rat.
PNN induced denervation in the nasal respiratory mucosa and reduced nasal secretion. In the allergic rhinitis model, PNN did not alleviate the nasal symptoms, such as sneezing and scratching, but reduced nasal secretion.
These findings suggest the posterior nasal nerve is not responsible primarily for regulation of allergic reactions.
|
| Free Research Field |
鼻科学
|
