2014 Fiscal Year Final Research Report
The effect of high glucose and high insulin state on beta-amyloid production
| Project/Area Number |
25893077
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | アルツハイマー型認知症 / インスリン / グルコース / アミロイドβ |
|---|
| Outline of Final Research Achievements |
Numerous epidemiological studies have shown that patients with diabetes mellitus (DM) have increased risk of developing Alzheimer disease(AD). We conducted a reserch to verify high glucose condition in AD pathogenesis and here provide following findings. i) high glucose condition faciletates β-amyoid(Aβ) production in cultured neuronal cells. ⅱ）high insulin state facilitates
Aβ production.
These findings suggest that hyperglycemia and hyperinsulinemia occurring in patients with DM may accelerate AD pathogenesis by facilitating Aβ production in neurons.
|
| Free Research Field |
認知症学
|
