2014 Fiscal Year Final Research Report
The Periodontal-Metabolic syndrome etiology via the intestine -the role of TRP channels-
| Project/Area Number |
25893079
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
NONAKA Yukari 新潟大学, 医歯学総合病院, 医員 (40710520)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 歯周炎 / TRPチャネル |
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| Outline of Final Research Achievements |
Periodontitis as periodontal bacterial infection has been implicated as a risk factor for diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. TRP channels are Ca2+ permeable cation channels, which play an important role in the pathogenesis and progression of inflammatory responses and metabolic disorders. The present study has demonstrated that TRPV1 can regulate inflammatory responses and lipid metabolism in the liver. This result suggests that TRP channel may affect the pathological mechanism of systemic diseases caused by periodontitis.
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| Free Research Field |
歯周病学
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