2014 Fiscal Year Final Research Report
Understanding the effect of lactate metabolism on cancer-mediated immunoregulation in head and neck cancer
| Project/Area Number |
25893085
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 腫瘍免疫 / がん代謝 / 頭頸部癌 / 乳酸 |
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| Outline of Final Research Achievements |
Understanding the effect of lactate metabolism on cancer-mediated immunoregulation in head and neck cancer, I analyzed gene expression in cancer by quantitative RT-PCR. Glucose transporters-1 (GLUT-1) and Lactate dehydrogenase-A (LDH-A), which are linked with enhanced glycolysis, have relevance for intratumor lactate concentration. Meanwhile, CD68 and CSF-1, which are known as M2 macrophage marker, have also relevance for intratumor lactate concentration. Furthermore, GLUT-1 and LDH-A have relevance for CD163 which is also known as M2 marker.
These results are suggest that the factors associated with enhanced glycolysis have somethings to do with M2 macrophage polarization. For cancer patients, the therapy targeting enhanced glycolysis is one potential strategy that improves the immunosuppressive status.
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| Free Research Field |
耳鼻咽喉科学
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