Elucidation of the expression pathway of adiponectin based on the integrated data analysis using epigenetic data

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893087
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Epidemiology and preventive medicine
• Research Institution: Nagoya University
• Principal Investigator: MASAHIRO Nakatochi 名古屋大学, 医学部附属病院, 病院助教 (10559983)
• Research Collaborator: YOKOTA Mitsuhiro 愛知学院大学, 歯学部, 教授 (50201851) ; MATSUBARA Tatsuaki 愛知学院大学, 歯学部, 教授 (30209598) ; ICHIHARA Sahoko 三重大学, 大学院地域イノベーション学研究科, 准教授 (20378326) ; YAMAMOTO Ken 久留米大学, 医学部, 教授 (60274528)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: エピゲノム / アディポネクチン / バイオインフォマティクス / DNAメチル化 / SNP / 生活習慣 / レジスチン

Outline of Final Research Achievements

Abnormal secretion of adiponectin and resistin is deeply involved in the development of lifestyle disease. These blood concentrations are known to be affected by the genetic factors. However, the variance of these concentrations explained by genes previously identified as associated genes with concentrations is very low.
In this study, we explored DNA methylation sites associated with the blood concentration of adiponectin and resistin using the data of blood concentration of them, SNP, and DNA methylation array for 192 nondiabetic men from a general population. As a result, we identified five sites for adiponectin and one site for resistin. Furthermore, DNA methylation level at the site associated with blood concentration of resistin was associated with SNP in vicinity of the site. These results suggest new insights into the regulation of blood concentration via effects on DNA methylation.

Free Research Field

バイオインフォマティクス