Perfusion CT to evaluate pancreatic stroma in pancreatic cancer mice model

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893105
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: TSUJI Yoshihisa 京都大学, 医学(系)研究科(研究院), その他 (10711541)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: Perfusion CT / 膵 / 膵癌 / 線維化

Outline of Final Research Achievements

In the present study, a significantly strong correlation was found between the imaging parameter (Fis) of perfusion CT, which targeted the contrast accumulation in the intstitial space and relects tumor-associated stroma in this model, and stromal density quantified using immunohistochemistry; this finding supported our hypothesis that perfusion CT had the potential to depict a similar spatial distribution of tumor-associated stroma to that confirmed using histopathological analysis. In terms of the association between tumor hypoxia and tumor-associated stroma, FMISO uptake had a negative correlation with Fis and stromal density, as well as with vascular parameters. These results suggest that tumor hypoxia was complementarily localized to tumor-associated stroma and the vascular component.

Free Research Field

膵臓学