C/EBP-alpha protects lung epithelial cells during CS-induced lung injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893106
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: SATO ATSUYASU 京都大学, 医学(系)研究科(研究院), 助教 (30706677)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: C/EBPα / 喫煙 / 再生

Outline of Final Research Achievements

Alveolar type 2 cells are critical for lung homeostasis including regeneration after lung injury. In the present study, regeneration process was evaluated using isolated alveolar type 2 cells. The proliferation and differentiation of alveolar type 2 cells were shown by FACS based methods and lineage trace murine model. C/EBP-alpha, epithelial specific transcription factor, was specifically knocked down in lung epithelial cells. Using this model, the protective function of C/EBP-alpha against cigarette smoke stimulation was shown

Free Research Field

呼吸器内科