2014 Fiscal Year Final Research Report
Development of novel 99mTc labeled amyloid imaging probes for diagnosis of Alzheimer's disease
| Project/Area Number |
25893109
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
|
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| Research Institution | Kyoto University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | 分子イメージング / 放射性医薬品 / SPECT / アルツハイマー病 |
|---|
| Outline of Final Research Achievements |
The deposition of β-amyloid (Aβ) peptides in the brain is a well-established biomarker of Alzheimer’s disease (AD). Since the deposition of Aβ plaques is considered to be the initial neurodegenerative event in AD, Aβ is the major target of early diagnosis and treatment for AD. In this study, we planned the development of novel probes labeled with technetium-99m (Tc-99m). Tc-99m has become the most commonly used radionuclide in diagnostic nuclear medicine. PQ-C3-BAT and 1,3,4-DPOD-2P-BAT which were developed in this study showed high affinity for Aβ aggregates in vitro. In addition, these probes showed initial uptake into and rapid clearance from the normal mouse brain. These results suggested that PQ-C3-BAT and 1,3,4-DPOD-2P-BAT may be potential probes for imaging Aβ plaques in AD brains.
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| Free Research Field |
分子イメージング学
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