2014 Fiscal Year Final Research Report
Expression control mechanism and function of immunosuppressive molecule PD-L1 in ovarian cancer
| Project/Area Number |
25893112
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
ABIKO Kaoru 京都大学, 医学(系)研究科(研究院), 助教 (20508246)
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | 卵巣癌 / 免疫 / PD-L1 / リンパ球 / インターフェロンガンマ / 腹膜播種 |
|---|
| Outline of Final Research Achievements |
In ovarian cancer clinical samples, the number of CD8-positive cells in cancer stroma was strongly correlated to PD-L1 expression on the tumor cells. In mouse models, depleting IFNGR1 resulted in lower level of PD-L1 expression in tumor cells, increased number of tumor-infiltrating lymphocytes, inhibition of tumor growth, and longer survival.
|
| Free Research Field |
婦人科腫瘍
|
