2014 Fiscal Year Final Research Report
The role for Mediator transcriptional coregulator complex in the property of breast carcinomas
| Project/Area Number |
25893130
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Mitsuhiro 神戸大学, 保健学研究科, 教授 (50362794)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 転写メディエーター / 乳癌 / MED1 |
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| Outline of Final Research Achievements |
We previously reported that Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells. In order to determine the role for MED1 and MED24 in the property of breast carcinomas, prognosis, and response to therapy, we have prepared, or are in the process of preparing, mice carrying various mutations in MED1, MED24, and MED1-associated factor. We have started analyses of these mutant mice that have been ready so far if these mice possess the ability of inhibiting breast cancer.
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| Free Research Field |
腫瘍検査学
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