2014 Fiscal Year Final Research Report
Elucidation of mechanism of antibody-related rejection bay using humanized immunodeficient mice lacking xenogeneic antigen
| Project/Area Number |
25893143
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | 移植免疫 |
|---|
| Outline of Final Research Achievements |
We aim to elucidate mechanism of antibody-mediated rejection in xenogeneic or allogeneic transplantation and develop the therapy in order to overcome chronic antibody-related rejection which is the most important issue in transplantation. We are now approaching establishment of the humanized mouse model during this period (①severe immunodeficient mice lacking Gal and NeuGc Ag, ②severe immunodeficient mice having human immune cells)
|
| Free Research Field |
外科学
|
