Bone regeneration by combination with human iPS cells and FGF18 in bone microenvironment-imitated Scaffold

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893157
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KOBAYASHI Masako 徳島大学, ヘルスバイオサイエンス研究部, 助教 (90706954)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: iPS細胞 / 骨再生 / FGF / スキャフォールド

Outline of Final Research Achievements

We focused on human induced Pluripotent Stem (iPS) cells, Fibroblast growth factors, and carbonate apatite as a scaffold in order to realize ideal bone tissue formation for bone regenerative medicine. Implantation of iPS cells with either carbonate apatite granules, calcium carbonate granules, or β-TCP granules to nude mice showed that bone like-structure surrounding the granules could be observed in carbonate apatite group and calcium carbonate group.

Free Research Field

口腔外科