2014 Fiscal Year Final Research Report
DC-Dependent efficient prevention of spontaneous neuroblastoma in MYCN transgenic mice
| Project/Area Number |
25893169
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 神経芽腫 |
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| Outline of Final Research Achievements |
Cultivation of lineage-negative hematopoietic progenitors from bone marrow of the mice of the same strain of MYCN transgenic mice in an optimized cytokine cocktail led to production of a large amount and high-purity dendritic cells.
Importantly, subcutaneous injection of the DCs pulsed with their tumor lysate almost completely prevents the tumor formation and much improved their survival in these mice. The depletion study of the effector cells suggested that the DC-therapy is dependent to CD4-positive cells.These results suggest that DC-based vaccine may possibly be a potential therapeutic to prevent neuroblastoma in clinical setting.
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| Free Research Field |
小児外科学
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