2013 Fiscal Year Final Research Report
Whole genome characterization of rotavirus strains circulating during a clinical trial of human rotavirus vaccine in Nha Trang, Vietnam.
| Project/Area Number |
25893181
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene and public health
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| Research Institution | Nagasaki University |
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Principal Investigator |
DOAN Hai Yen 長崎大学, 医歯(薬)学総合研究科, 助教 (90701243)
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| Project Period (FY) |
2013-08-30 – 2014-03-31
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| Keywords | ロタウイルス / ワクチン / 遺伝子型 / 野生株 / 有効性 / 全ゲノム解析 |
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| Research Abstract |
In an attempt to get insight into the cause of lower efficacy of rotavirus vaccines in developing countries, whole genome analysis was performed on G1P[8] and G3P[8] strains that predominated during a clinical trial of the pentavalent rotavirus vaccine in Vietnam. Their genotype constellation was found to be G1/G3-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-E1-H1. Taken together with the result of the phylogenetic analysis, it was concluded that rotavirus strains circulating in Vietnam was no more different than the strains circulating in high-income countries. Thus, the lower efficacy is unlikely to be explained by the diversity of circulating strains.
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