2014 Fiscal Year Final Research Report
Elucidation of mitochondrial fission/fusion and mitophagy in Parkinson's disease
| Project/Area Number |
25893237
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
|
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| Research Institution | Juntendo University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | パーキンソン病 / ミトコンドリア |
|---|
| Free Research Field |
パーキンソン病
|
| Outline of Final Research Achievements |
I observed that mitochondrial fission was induced by VPS35 gene, one of Parkinson's disease (PD) causative gene, over-expression into human derived cultured cells using a fluorescence microscope live-imaging. However, I was not able to elucidate association between VPS35 and mitophagy. Based on these, I can consider that VPS35 regulates mitochondrial morphology and disruption of mitochondrial morphological regulation could lead to onset of PD
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