2014 Fiscal Year Final Research Report
Identification of enhanced salivary gland stem cell regenerative capacity factor and its application to treatment of disease
| Project/Area Number |
25893240
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 唾液腺 / 幹細胞 / 再生 |
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| Outline of Final Research Achievements |
As an analysis of the factors that is specifically expressed fetal salivaly gland, from head and neck frozen tissue sections of embryonic day 12 old mice, two areas of the oral mucosa and salivary gland were collected using laser microdissection. In addition, the CD133-positive cells from adult submandibular glands were collected by flow-cytometory as salivary gland adult stem cells. And we analyzed embryonic stage salivary gland and salivary gland adult stem cells gene expression profiles using RNA sequence. Using in situ hybridization for high transcription factor of both population, it was confirmed localization in adult submandibular gland and fetal salivaly gland.
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| Free Research Field |
再生医療
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