2014 Fiscal Year Final Research Report
The roles of Rho family GTPases in inflammatory bone destruction
| Project/Area Number |
25893243
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
AIZAWA Ryo 昭和大学, 歯学部, 助教 (80710673)
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | 遺伝子改変動物 / 炎症性骨破壊 |
|---|
| Outline of Final Research Achievements |
We may find the technique that is useful in prevention or treatment of disease with bone destruction by investigating roles of Rho family GTPases in bone resorption. Therefore, we generated osteoclast-specific inactivated Rac1 and Cdc42 mice to investigate the physiological functions of Rac1 and Cdc42 in bone resorption.
As a result, our findings suggest that Rac1 and Cdc42 play important roles for bone resorption caused by osteoclast formation in vivo.
|
| Free Research Field |
歯周病学
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